William Nylander added two on the power play to go along with an assist and Ilya Mikheyev had a short-handed goal as part of his first three-point night in the NHL for the Leafs.
Mark Giordano, with a goal and an assist, John Tavares and Timothy Liljegren also scored Toronto (43-19-5), which got 20 saves from Erik Kallgren. Mitch Marner added three assists.
Nikolaj Ehlers, with a goal and an assist, Blake Wheeler and Paul Stastny replied for Winnipeg (33-26-10). Eric Comrie stopped 31 shots.
The Leafs were coming off key victories over the Florida Panthers and Boston Bruins in the race for Atlantic Division playoff seeding, while the Jets picked up a crucial 3-2 shootout victory against the Buffalo Sabres on Wednesday as they continue to battle for a wild-card spot in the Western Conference.